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With over 200 million unemployed women and men, governments around the world are faced with the daunting challenge of providing productive livelihoods for their citizens. Entrepreneurship is an important piece in any development framework. It allows people to create jobs for themselves and for others, it helps reduce poverty by creating thriving and inclusive economies, and it stimulates innovation and invention. This discussion will highlight the role of government regulation in enabling private enterprise – to start, operate and expand.